Longevity blood test: the markers with the strongest evidence, and who tests them

The short answer on longevity blood tests

"Longevity blood test" is a marketing term, not a medical one. Stripped of hype, it means testing the blood markers that best predict heart disease, diabetes, kidney and liver disease, the conditions that cut most healthy years short. The ones with guideline-level evidence are ApoB, Lp(a), HbA1c, eGFR and a standard lipid panel, with hs-CRP, liver enzymes, ferritin and hemoglobin close behind. SiPhox Longevity Essentials covers ApoB, Lp(a), HbA1c, hs-CRP, ferritin and hemoglobin at home for $124 plus $25 shipping. Its Heart & Metabolic panel swaps in kidney and liver markers, and Ultimate 360 has all of them.

The core longevity markers, at homeSiPhox Longevity Essentials: ApoB, Lp(a), HbA1c, hs-CRP and 27 more from a needle-free arm draw. $124 plus $25 shipping.

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Longevity markers, ranked by the strength of evidence

We grouped markers by what the major guidelines say, not by what longevity clinics sell. Blood pressure, waist size, fitness and smoking status matter as much as any of these, but they are not blood tests, so they sit outside this table. "Guideline" means a US or international clinical guideline recommends measuring it in at least some adults.

Reference points for the core markers

Each marker needs a number to read it against. These are the guideline cut-offs this page uses; your lab's printed range may differ, so check your own report.

Which services test each longevity marker

This table is built from each panel's published biomarker list (checked September 29, 2026).

The pattern is clear. Longevity Essentials is strongest on heart and metabolic risk but has no kidney or liver markers. Heart & Metabolic adds eGFR, creatinine, ALT and AST but drops vitamin D, ferritin and hormones. Ultimate 360 covers everything on this list except cystatin C, for $249 plus shipping. Because you can switch SiPhox panels every test, alternating Longevity and Heart & Metabolic covers most of the list at the base price.

The lab-draw memberships go wider. Superpower's published panel includes ApoB, Lp(a), hs-CRP, cystatin C, eGFR, ALT, GGT, ferritin, vitamin D and homocysteine across 150+ markers a year for $349. Function Health covers 160+ tests a year for $365. Both need a venous draw at Quest; see SiPhox vs Function Health for the trade-off.

Most people start here

Longevity Essentials

$124 + $25 shipping per test

31 biomarkers per test

The default panel: heart, metabolic, hormone and inflammation markers in one draw.

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Heart & Metabolic

$124 + $25 shipping per test

28 biomarkers per test

Lipids plus kidney and liver function: the panel for cardiovascular and metabolic risk.

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Ultimate 360

$249 + $25 shipping per test

62 biomarkers per test

Everything on the four core panels plus iron studies, B12 and folate, GGT and PSA.

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What SiPhox Longevity Essentials leaves out

To be clear about the gaps: the default SiPhox panel has no kidney or liver markers, no fasting insulin or HOMA-IR, no cystatin C, no homocysteine, no full blood count and no omega-3 index. Kidney and liver markers are on Heart & Metabolic and Ultimate 360. A complete blood count is a +$45 add-on and IGF-1 a +$70 add-on on EasyDraw panels. If fasting insulin is a priority, see our insulin resistance test guide, because no current SiPhox EasyDraw panel measures it; SiPhox reports C-peptide and the triglyceride to HDL ratio instead.

Popular longevity markers with weaker evidence

• Vitamin D. The Endocrine Society's 2024 guideline suggests against routine vitamin D testing in healthy adults under 75, because there is no evidence that routine testing improves outcomes. It still makes sense if you have risk factors for deficiency. See our vitamin D test guide.
• Biological age scores. Several services compute a "biological age" from standard markers. They are interesting to track but none is validated as a target for treatment.
• Homocysteine. Often sold as a longevity marker. Superpower includes it; SiPhox's current EasyDraw panels do not.
• Huge panels. Testing 150 markers raises the chance of a false alarm. More markers are not better unless you would act on them.

Questions to ask before you buy any longevity panel

• Does it include ApoB and Lp(a)? If not, it is missing the two heart markers with the newest guideline support.
• Does it include kidney and liver markers? eGFR and ALT are cheap and informative; some at-home panels skip them.
• Who reviews the results? SiPhox and Rythm do not include a doctor review; Function Health adds clinician notes.
• Can you retest just the markers you are changing? Paying for 150 markers to track three is poor value.
• What does a year cost with shipping and add-ons, not just the headline price?
• Is it available where you live? SiPhox does not serve New York or Hawaii, and some lab-draw services charge more in New York and New Jersey.

A sensible longevity testing plan

1. Baseline once: the full list above, including Lp(a), which usually only needs measuring once in a lifetime. Ultimate 360 or a lab-draw membership does this in one go.
2. Track what you can change: ApoB, HbA1c, hs-CRP and liver enzymes respond to diet, exercise, weight and medication. Retest every 3 to 6 months while you are making changes, then once or twice a year.
3. Act through your doctor: none of these services diagnose disease. Take anything outside the reference range to your doctor, and ask for a standard venous test to confirm it.

What a year of longevity testing costs

Here are four realistic plans, priced with shipping at September 29, 2026 list prices. SiPhox's first test for new members is advertised at $99 plus shipping, which would take $25 off the first year.

If you only want breadth once a year, a lab-draw membership is cheaper. If you want to see ApoB, HbA1c and hs-CRP move while you change something, or you will not go to a lab, SiPhox is the better fit. Our cost calculator runs other combinations, and the best at-home blood test ranking compares all six services.

Which longevity test to choose

Reading trends, not single results

Every lab result has some normal variation: the same person tested twice in a week will not get identical numbers. hs-CRP is the best example; the CDC/AHA statement recommends averaging two measurements taken about two weeks apart and ignoring a result above 10 mg/L, which usually means an infection or injury rather than chronic inflammation. So:

• Look for direction over two or three tests, not a single jump.
• Keep conditions the same: time of day, fasting or not, no hard workout or illness in the days before.
• Stick with one service for tracking. Different labs use different methods and ranges, which can look like a change when nothing changed.
• Separate "out of range" from "trending the wrong way". The first needs a doctor; the second is a prompt to look at what changed in your routine.

Start with the markers that matterLongevity Essentials is SiPhox's default panel. Retest monthly, quarterly or twice a year and switch panels each time.

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Frequently asked questions