Quick answer
What does SiPhox test for? Heart, metabolic, inflammation, thyroid, hormone, nutrient, liver and kidney markers, depending on the panel you pick. Every SiPhox membership test includes one panel, and you can switch each time. The four core panels are included in the $124 price (plus $25 shipping): Longevity Essentials (31 biomarkers), Heart & Metabolic (28), Thyroid Focus (21) and Hormone Focus (14). GLP Optimization (40+ markers) costs $75 more per test and Ultimate 360 (62) costs $125 more. Counts include calculated ratios and a few sex-specific markers. All panels use the needle-free EasyDraw upper-arm device.
All SiPhox panels at a glance
Prices read from SiPhox's pricing pages on September 29, 2026, including $25 US shipping.
| Panel | Biomarkers per test | Upgrade cost | Per test, with shipping | Cost per biomarker |
|---|---|---|---|---|
| Longevity Essentials | 31 | Included | $149 | $4.81 |
| Heart & Metabolic | 28 | Included | $149 | $5.32 |
| Thyroid Focus | 21 | Included | $149 | $7.10 |
| Hormone Focus | 14 | Included | $149 | $10.64 |
| Ultimate 360 | 62 | +$125 | $274 | $4.42 |
| GLP Optimization | 46 | +$75 | $224 | $4.87 |
Each core panel is also sold as a one-off kit for $149 without a membership, and Ultimate 360 for $274. For the full price breakdown by cadence see SiPhox cost.
SiPhox panel pages, checked 29 Sep 2026. Counts include calculated ratios. GLP Optimization is advertised as "40+" with 46 listed; Ultimate 360 is 52 in Canada.
Our arithmetic from prices checked 29 Sep 2026: $149 per core panel, $224 for GLP and $274 for Ultimate 360 (all with $25 US shipping), divided by markers per test.
The two charts pull in opposite directions. Hormone Focus is the smallest panel and the most expensive per marker, at $10.64, because it costs the same $149 as the 31-marker Longevity Essentials. Ultimate 360 is the cheapest per marker at $4.42, but it is $125 more per test. If you want hormones anyway, Longevity Essentials gives men testosterone, free testosterone and SHBG, and women estradiol, FSH and LH, at less than half the cost per marker.
SiPhox Longevity Essentials: 31 biomarkers
The default panel and the one most members start with. It covers the heart markers most routine checkups skip, ApoB and Lp(a), alongside HbA1c, hs-CRP, TSH, vitamin D and ferritin. Hormones differ by sex: men get total and free testosterone and SHBG; women get sensitive estradiol, FSH and LH. The list below has 33 entries because of those sex-specific markers.
| Area | Listed | Biomarkers |
|---|---|---|
| Heart | 12 | ApoB, Lipoprotein (a), Total cholesterol, HDL cholesterol, Calculated LDL cholesterol, Triglycerides, VLDL cholesterol, ApoA1, ApoB:ApoA1 ratio, LDL-C:ApoB ratio, LDL-C:HDL-C ratio, Total cholesterol:HDL ratio |
| Metabolic | 5 | HbA1c, Estimated average glucose, C-peptide, Triglycerides:HDL ratio, Cortisol |
| Inflammation | 1 | hs-CRP |
| Thyroid | 1 | TSH |
| Hormones | 10 | Total testosterone (men), Free testosterone, calculated (men), SHBG (men), DHEA-S, Estradiol, sensitive (women), FSH (women), LH (women), LH:FSH ratio (women), Testosterone:cortisol ratio, Cortisol:DHEA-S ratio |
| Nutrition | 2 | Vitamin D (25-OH), Ferritin |
| Blood | 2 | Hemoglobin, Hematocrit (calculated) |
Not included: kidney and liver markers, free T4 or thyroid antibodies, B12, iron studies, PSA.
SiPhox Heart & Metabolic: 28 biomarkers
Swaps the hormones and nutrients for kidney and liver function. Pick it once or twice a year to check eGFR, creatinine, ALT and AST, especially on long-term medication such as a statin or GLP-1. It drops ApoA1 and the ApoB ratios but keeps ApoB and Lp(a).
| Area | Listed | Biomarkers |
|---|---|---|
| Heart | 9 | ApoB, Lipoprotein (a), Total cholesterol, HDL cholesterol, Calculated LDL cholesterol, Triglycerides, VLDL cholesterol, LDL-C:HDL-C ratio, Total cholesterol:HDL ratio |
| Metabolic | 4 | HbA1c, C-peptide, Cortisol, Triglycerides:HDL ratio |
| Inflammation | 1 | hs-CRP |
| Thyroid | 1 | TSH |
| Kidney | 4 | eGFR, Creatinine, BUN, BUN:creatinine ratio |
| Liver | 6 | ALT, AST, ALP, Total bilirubin, Direct bilirubin, AST:ALT ratio |
| Nutrition | 1 | Total protein |
| Blood | 2 | Hemoglobin, Hematocrit (calculated) |
SiPhox Thyroid Focus: 21 biomarkers
A full thyroid workup: TSH, free T4, free T3, both thyroid antibodies (TPO and thyroglobulin) and two ratios, plus ferritin, cortisol and a small lipid, liver and kidney set. It does not include ApoB or HbA1c. See our at-home thyroid test guide for how it compares.
| Area | Listed | Biomarkers |
|---|---|---|
| Thyroid | 7 | TSH, Free T4, Free T3, TPO antibodies, Thyroglobulin antibodies, Free T3:free T4 ratio, TSH:T4 ratio |
| Heart | 4 | HDL cholesterol, Calculated LDL cholesterol, Triglycerides, LDL-C:HDL-C ratio |
| Metabolic | 2 | Cortisol, Triglycerides:HDL ratio |
| Inflammation | 1 | hs-CRP |
| Hormones | 1 | SHBG |
| Nutrition | 1 | Ferritin |
| Liver | 3 | ALT, AST, AST:ALT ratio |
| Kidney | 2 | Creatinine, eGFR |
SiPhox Hormone Focus: 14 biomarkers
The sex-hormone panel for men and women. It is the only core panel with progesterone, prolactin, PSA (men) and the free androgen index, and the only way to get estradiol for men without Ultimate 360. SiPhox reports 14 markers per test, and lists more across both sexes. It has no heart, metabolic or thyroid markers beyond albumin and cortisol, so most people rotate it with Longevity Essentials. See at-home testosterone test.
| Area | Listed | Biomarkers |
|---|---|---|
| Hormones | 13 | Total testosterone, Free testosterone (calculated), % free testosterone, SHBG, Estradiol (sensitive), Progesterone, LH, FSH, LH:FSH ratio, Prolactin, DHEA-S, Free androgen index, Cortisol:DHEA-S ratio |
| Metabolic | 2 | Albumin, Cortisol |
| Prostate | 1 | PSA (men) |
SiPhox Ultimate 360: 62 biomarkers
Everything on the four core panels in one test, plus iron studies (iron, TIBC, UIBC, saturation), vitamin B12, folate, GGT and PSA. It costs $125 more per test ($274 with shipping). Reviewers say it needs several EasyDraw devices, so set aside more time for collection. Ultimate 360 is the closest SiPhox gets to a full body blood test.
| Area | Listed | Biomarkers |
|---|---|---|
| Heart | 12 | ApoB, Lipoprotein (a), Total cholesterol, HDL cholesterol, Calculated LDL cholesterol, Triglycerides, VLDL cholesterol, ApoA1, ApoB:ApoA1 ratio, LDL-C:ApoB ratio, LDL-C:HDL-C ratio, Total cholesterol:HDL ratio |
| Metabolic | 6 | HbA1c, Estimated average glucose, C-peptide, Albumin, Cortisol, Triglycerides:HDL ratio |
| Inflammation | 1 | hs-CRP |
| Thyroid | 7 | TSH, Free T4, Free T3, TPO antibodies, Thyroglobulin antibodies, Free T3:free T4 ratio, TSH:T4 ratio |
| Hormones | 14 | Total testosterone, Free testosterone (calculated), % free testosterone, SHBG, Estradiol (sensitive), Progesterone, LH, FSH, LH:FSH ratio, Prolactin, DHEA-S, Free androgen index, Testosterone:cortisol ratio, Cortisol:DHEA-S ratio |
| Nutrition | 9 | Vitamin D (25-OH), Ferritin, Iron, TIBC, UIBC, Iron saturation, Vitamin B12, Folate, Total protein |
| Liver | 7 | ALT, AST, ALP, GGT, Total bilirubin, Direct bilirubin, AST:ALT ratio |
| Kidney | 4 | eGFR, Creatinine, BUN, BUN:creatinine ratio |
| Prostate | 1 | PSA (men) |
| Blood | 2 | Hemoglobin, Hematocrit (calculated) |
SiPhox GLP Optimization: 40+ biomarkers
Built for people on GLP-1 medication such as semaglutide or tirzepatide. SiPhox advertises "40+ lab markers" and lists 46: metabolic, lipid, liver, kidney, nutrient and iron markers, plus morning cortisol. It costs $75 more per test ($224 with shipping). It has no Lp(a), no thyroid antibodies and no PSA. More in the GLP-1 blood test guide.
| Area | Listed | Biomarkers |
|---|---|---|
| Metabolic | 6 | HbA1c, Estimated average glucose, C-peptide, Albumin, Total protein, Morning cortisol |
| Heart | 10 | ApoB, Total cholesterol, HDL cholesterol, Calculated LDL cholesterol, Triglycerides, VLDL cholesterol, Triglycerides:HDL ratio, LDL-C:HDL-C ratio, LDL-C:ApoB ratio, Total cholesterol:HDL ratio |
| Inflammation | 1 | hs-CRP |
| Liver | 7 | ALT, AST, ALP, GGT, Total bilirubin, Direct bilirubin, AST:ALT ratio |
| Kidney | 4 | BUN, Creatinine, eGFR, BUN:creatinine ratio |
| Thyroid | 3 | TSH, Free T4, TSH:T4 ratio |
| Hormones | 5 | SHBG, Total testosterone (men), Free testosterone (calculated), % free testosterone, Estradiol (sensitive) |
| Nutrition | 8 | Vitamin D (25-OH), Vitamin B12, Folate, Ferritin, Iron, TIBC, UIBC, Iron saturation |
| Blood | 2 | Hemoglobin, Hematocrit (calculated) |
Key biomarkers by panel
Generated from the lists above. "Men only" or "Women only" means the panel reports the marker for one sex.
| Biomarker | Longevity Essentials | Heart & Metabolic | Thyroid Focus | Hormone Focus | Ultimate 360 | GLP Optimization |
|---|---|---|---|---|---|---|
| ApoB | Yes | Yes | No | No | Yes | Yes |
| Lp(a) | Yes | Yes | No | No | Yes | No |
| hs-CRP | Yes | Yes | Yes | No | Yes | Yes |
| HbA1c | Yes | Yes | No | No | Yes | Yes |
| C-peptide | Yes | Yes | No | No | Yes | Yes |
| TSH | Yes | Yes | Yes | No | Yes | Yes |
| Free T4 | No | No | Yes | No | Yes | Yes |
| Free T3 | No | No | Yes | No | Yes | No |
| TPO antibodies | No | No | Yes | No | Yes | No |
| Total testosterone | Men only | No | No | Yes | Yes | Men only |
| Estradiol | Women only | No | No | Yes | Yes | Yes |
| Progesterone | No | No | No | Yes | Yes | No |
| PSA | No | No | No | Men only | Men only | No |
| Ferritin | Yes | No | Yes | No | Yes | Yes |
| Iron saturation | No | No | No | No | Yes | Yes |
| Vitamin D | Yes | No | No | No | Yes | Yes |
| Vitamin B12 | No | No | No | No | Yes | Yes |
| eGFR | No | Yes | Yes | No | Yes | Yes |
| ALT | No | Yes | Yes | No | Yes | Yes |
| GGT | No | No | No | No | Yes | Yes |
| Cortisol | Yes | Yes | Yes | Yes | Yes | Yes |
Which SiPhox panel should I pick?
| Your goal | Panel | Why |
|---|---|---|
| General prevention, first test | Longevity Essentials | Broadest core panel: ApoB, Lp(a), HbA1c, hs-CRP, hormones, nutrients |
| Heart risk plus kidney and liver | Heart & Metabolic | Adds eGFR, creatinine, BUN, ALT, AST, ALP, bilirubin |
| Tiredness, weight change, thyroid history | Thyroid Focus | TSH, free T4, free T3, TPO and Tg antibodies |
| Low libido, TRT, cycle or PCOS questions | Hormone Focus | Full sex-hormone panel with PSA and progesterone |
| On GLP-1 medication | GLP Optimization | Liver, kidney, protein, B12, iron and lipids as weight changes |
| One complete baseline a year | Ultimate 360 | All of the above except GLP extras, 62 markers |
Say you join in January on a quarterly cadence and switch panels at each renewal. January: Longevity Essentials, $124 with the new-member price. April: Heart & Metabolic, $149. July: Thyroid Focus, $149. October: Hormone Focus, $149. Year one costs $571 and returns 31 + 28 + 21 + 14 = 94 results, with ApoB and Lp(a) twice, kidney and liver once, a full thyroid workup once and a full sex-hormone panel once. Ultimate 360 every quarter would return 248 results for $1,096, and a single Ultimate 360 covers nearly everything in the rotation for $274, but only as one snapshot.
A common pattern: Ultimate 360 once a year and Longevity Essentials the other three quarters, for $721 a year. For men and women specifically, see at-home blood test for men and for women.
Longevity Essentials
The default panel: heart, metabolic, hormone and inflammation markers in one draw.
Check price
Heart & Metabolic
Lipids plus kidney and liver function: the panel for cardiovascular and metabolic risk.
Check price
Ultimate 360
Everything on the four core panels plus iron studies, B12 and folate, GGT and PSA.
Check priceAdd-ons
| Add-on | Price per test | Notes |
|---|---|---|
| Complete blood count (CBC) | +$45 | Hematocrit, hemoglobin, MCH, MCHC, MCV, RBC, RDW, WBC |
| IGF-1 | +$70 | Growth hormone marker |
| CBC and IGF-1 together | +$100 | |
| Hormone+, Thyroid+ or Metabolic+ | +$50 each | Stackable marker bundles |
| Advanced BioAge Report | +$50 | Longevity and Heart panels |
| Health expert results review | +$50 | The only way to have someone review results with you |
SiPhox also sells separate one-off products: a Kidney, Liver and Lp(a) panel (12 markers, $85), a 4-point saliva cortisol test ($120), a gut microbiome test ($229) and a food and environmental allergy panel ($225).
What SiPhox does not test
None of the current EasyDraw panels include:
- Fasting insulin and HOMA-IR. SiPhox uses C-peptide, HbA1c and the triglyceride:HDL ratio instead. See HOMA-IR.
- Glucose. Capillary glucose tends to read high and falls during shipping, so SiPhox relies on HbA1c.
- Homocysteine and cystatin C. Both appeared on older finger-prick panels and are still listed on SiPhox's legacy pages, which causes confusion.
- AMH, the ovarian reserve marker.
- Omega-3 index and magnesium.
- Electrolytes and calcium (sodium, potassium, chloride, carbon dioxide, calcium).
- Platelets and a white cell differential, even with the CBC add-on as listed.
If you need any of these, a lab-draw service may fit better; compare SiPhox vs Function Health.
Why the counts differ across SiPhox pages
SiPhox's own pages disagree. Ultimate 360 is listed as 60 biomarkers in the FAQ, 62 on the panel page and 65 on the partner page (and 52 in Canada). An April 2026 SiPhox article gives older counts: Longevity 29, Heart 26. We use the per-test counts on the panel pages as of September 29, 2026, and the lists above are the markers SiPhox shows for each panel. Counts also include calculated values such as the ApoB:ApoA1 ratio, estimated average glucose and calculated LDL, which are derived from other results rather than measured separately. Our SiPhox review covers accuracy, turnaround and complaints.
Frequently asked questions
What does SiPhox test for?
Depending on the panel: heart (ApoB, Lp(a), lipids), metabolic (HbA1c, C-peptide), inflammation (hs-CRP), thyroid, sex hormones, cortisol, nutrients (vitamin D, ferritin, B12, iron), liver, kidney and PSA. Core panels cover 14 to 31 markers; Ultimate 360 covers 62.
What is included in SiPhox Ultimate 360?
62 biomarkers per test in the US: everything on the four core panels plus iron studies, vitamin B12, folate, GGT and PSA. It costs $125 more per test, $274 with shipping.
What is the difference between SiPhox Longevity Essentials and Heart & Metabolic?
Longevity Essentials (31) includes hormones, vitamin D, ferritin, ApoA1 and the ApoB ratios. Heart & Metabolic (28) drops those and adds kidney (eGFR, creatinine, BUN) and liver (ALT, AST, ALP, bilirubin) markers.
Does SiPhox test fasting insulin?
No. Current EasyDraw panels measure C-peptide, HbA1c and the triglyceride:HDL ratio instead of fasting insulin or HOMA-IR.
Can I switch SiPhox panels?
Yes. Each membership test includes one panel, and you can switch between the four core panels, or upgrade to GLP Optimization or Ultimate 360, before each test.
Does SiPhox Hormone Focus include PSA?
Yes, for men. Hormone Focus and Ultimate 360 are the only SiPhox panels that include PSA.
Sources
- SiPhox Health: membership, panels and pricing (checked 29 Sep 2026)
- SiPhox Health FAQ
- SiPhox Health panel comparison
- SiPhox Health: Longevity Essentials panel page
- SiPhox Health: Heart & Metabolic panel page
- SiPhox Health: Thyroid Focus panel page
- SiPhox Health: Hormone Focus panel page
- SiPhox Health: Ultimate 360 panel page
- SiPhox Health: GLP Optimization panel
- SiPhox Health shop: one-off kits and add-ons
- SiPhox Health: Kidney, Liver and Lp(a) panel
- SiPhox: how much is at-home blood testing (SiPhox answers, April 2026)
- Trustpilot: SiPhox Health reviews
- Diagnostics (Basel) 2025: evaluation of a simplified upper-arm device for vacuum-assisted collection of capillary blood